A major breakthrough! A macrophage sensor that diagnoses early cancer

Endogenous biomarkers remain an indicator of early diagnosis of many diseases, but many markers lack the sensitivity and specificity to effectively guide disease control, which allows early diagnosis of disease and monitoring of disease progression. Treatment has become a problem.
In order to solve this problem, researchers from the Stanford University School of Medicine recently developed a cell-based in vivo biosensor under the leadership of Professor Sanjiv S. Gambhir of the Department of Bioengineering, Radiology, and Molecular Imaging to achieve high sensitivity. Early diagnosis of sexual tumors .
The researchers genetically engineered macrophages to combine luciferase expression with activation of the arginase-1 promoter, allowing these macrophages to sense M2-type tumor-associated metabolic profiles to produce fluorescein. Enzyme.
After successful cell construction, the researchers returned these cells to a mouse model of colorectal cancer and breast cancer, and found that these macrophages can migrate to the tumor site and activate the expression of arginase-1, which makes the study Personnel can diagnose tumors by bioluminescence imaging and by detecting the amount of luciferase in the blood.
The researchers found that by detecting luciferase in the blood, this macrophage sensor can detect tumors that are 25-50 cubic millimeters in size in the presence of inflammation, which is more than the cancer-related proteins currently used clinically. Diagnostic methods for nucleic acid biomarkers are more sensitive.
In addition, the researchers found that this macrophage sensor can effectively track the immune response in muscle and lung inflammation models, suggesting that this method can also be applied to the detection of other diseases other than cancer.
Reference: Sanjiv S. Gambhir et al. Engineered immune cells as highly sensitive cancer diagnostics. Nature Biotechnology (2019). DOI https://doi.org/10.1038/s41587-019-0064-8

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Accuracy

±1 mm (0.04 inch)

Measuring Unit

meter/inch/feet

Measuring Range (without Reflection)

0.03-150m

Measuring Time

0.1~3 seconds

Laser Class

Class II

Laser Type

635nm, <1mW

Size

45*25*12mm (±1 mm)

Weight

About 10g

Voltage

DC2.0~3.3V

Electrical Level

TTL/CMOS

Frequency

10Hz

Operating Temperature

0-40 ℃ (32-104 ℉ )

Storage Temperature

-25~60 ℃ (-13~140 ℉)


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