Release date: 2018-06-04
A magical stem cell can rejuvenate the brain with little self-healing power. According to a report by the Australian ScienceAlert website on April 7, a new study published in the journal Science found that if a static stem cell located in the brain is activated, it can help the brain repair damage and even cure Alzheimer's disease. This type of neurodegenerative disease.
Neurodegenerative diseases are diseases in which the brain neurons of the brain and spinal cord are lost, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. Because the cells of the brain and spinal cord cannot regenerate, such diseases are often irreversible, leading to a large number of brain cells that die and die, often causing lifelong disability and even memory loss.
Researchers at the University of Cambridge in the UK have discovered a potential regenerative "G2 resting stem cell" in the brain. Like other stem cells, it is not fully differentiated, yet immature, and has the potential to regenerate various functional cells. However, "G2 quiescent stem cells" have been sleeping, the researchers said, it is currently not effective to activate
However, this research has made some progress worth celebrating. According to researcher Andrea Brand, 60% of genes in human flies that are similar to human diseases can be used as an effective animal model. The tribbles gene in Drosophila can specifically regulate "G2 quiescent stem cells". If the drug can be used to target the tribbles gene, it is very likely to activate "G2 quiescent stem cells" to produce new neurons and glial cells.
"The brain is not good at self-repair, but these new findings suggest that we can improve its ability to regenerate." Andrea Brand said that experiments involving the flies tribbles gene can be carried out in the human brain, and their next plan is to The function of the tribbles gene is verified in brain cells, and a drug molecule capable of awakening "G2 quiescent stem cells" is sought.
At the same time, the researchers believe that cells that are still asleep like "G2 quiescent stem cells" may still be present in other organs. If we can find ways to activate and utilize these stem cells, we can develop drugs to treat the disease, even without traumatic surgery.
Source: Life Sciences
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