Early life malnutrition increases asthma risk
February 12, 2019 Source: Health News Network
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, the research team led by Academician Huang Hefeng, affiliated to the International Peace Maternal and Child Health Hospital of Shanghai Jiaotong University School of Medicine and Shanghai Key Laboratory of Embryonic Diseases, has made new discoveries in embryogenic diseases. The team used a mouse model of early life malnutrition to reveal that early nutritional status affects the function of mouse immune cells by regulating their metabolic levels and epigenetics, and ultimately affects the incidence of offspring asthma. Related papers are published online in the Journal of Allergy and Clinical Immunology.
Epidemiological investigations have found that intrauterine growth restriction can affect the development and function of the respiratory system of the offspring, and significantly increase the risk of asthma, but its mechanism is still unclear. The researchers used protein restriction to simulate the state of malnutrition, and constructed a mouse model of malnutrition in early life. After the offspring were given adulthood, they were given allergens to the lungs. It was found that mice with malnutrition in early life were more nutritious than those in early life. The mouse is susceptible to experimental asthma. No signs of exacerbation of asthma were found in female offspring, which may be related to the gender preference of developmental diseases. It is noteworthy that the researchers found that maternal gestational nutrition, ie, the nutritional status of the uterus, has a greater impact on the susceptibility to experimental asthma in the offspring than in the lactation.
CD4+ T lymphocytes play a key role in the pathogenesis of allergic asthma. The researchers found that the activation and proliferation of CD4+ T lymphocytes in malnourished mice was significantly enhanced in mice with normal trophic nutrition in early life, both in vitro and in the asthma model. The function and fate of CD4+ T lymphocytes are determined by tight regulation of metabolic levels and epigenetic modifications. Using techniques such as metabolic analysis, the researchers found that mice with malnourished early life showed a stronger rate of glycolysis after activation of CD4+ T lymphocytes, while the rate of oxidative phosphorylation did not change significantly. Importantly, the function and differentiation of CD4+ T lymphocytes in malnourished mice were significantly inhibited when the glycolytic pathway was blocked, and experimental asthma symptoms were also significantly alleviated.
In addition, the study clarified that the nutritional status of maternal pregnancy regulates its function and fate by remodeling the metabolic and epigenetic levels of the immune cells themselves, ultimately affecting the onset of asthma in adult offspring.
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