Release date: 2014-05-09
A recent study by Chinese scientists found that there is a relationship between the protein "angiotensin II" in human plasma and the mortality rate of H7N9 avian influenza. The higher the "angiotensin II" index, the higher the mortality rate of H7N9 avian influenza patients. .
The research results were jointly completed by the First Affiliated Hospital of Zhejiang University School of Medicine and the researchers of the Chinese Academy of Medical Sciences and the Chinese Center for Disease Control and Prevention. They were published in the journal Nature-Communication on May 6th, Beijing time. This is also the first time scientists have discovered and reported a correlation between individual proteins and H7N9 avian influenza disease.
"Angiotensin II" exists in human plasma, blood vessel wall, heart, kidney and other tissues. Its main function is to regulate blood pressure and maintain water and electrolyte balance, and it is closely related to the occurrence and development of acute lung injury.
The research team collected the plasma of 47 confirmed cases of H7N9 avian influenza in Hangzhou, Shanghai and Nanjing. After analyzing the angiotensin II and viral load, the researchers found that the plasma of H7N9 avian influenza patients was severe. "Angiotensin II" was significantly higher than the control group, and the higher the "angiotensin II" level, the more viral load in the body.
"This feature is particularly evident in the second week after onset. The angiotensin II' index is generally elevated in critically ill patients, including 8 deaths, but this indicator for mild patients will be available in the second week. "The decline." Li Lanjuan, an expert on the prevention and control of the H7N9 bird flu epidemic, led by the leader of the results and the National Health and Family Planning Commission, said.
Further studies have found that "angiotensin II" predicts the severity of H7N9 avian influenza and the accuracy of fatality compared to previously measured C-reactive protein, oxygenation index and other clinical indicators.
Prior to this, due to the lack of large enough sample analysis statistics, it is difficult for researchers to find out the relationship between the changes of individual proteins in human plasma and the severity and development of the disease. Clinically, the severity of H7N9 avian influenza virus infection is not predicted. And markers of disease progression.
"This discovery can make this protein for clinical use, as the first warning indicator for the severity of H7N9 patients, predicting the fatality of patients' diseases." Li Lanjuan said. The Chinese Academy of Engineering said that this will help medical staff to take different rescue measures according to patients with different conditions, so that the treatment is more reliable and effective.
"The results of this research will provide new insights into the study of avian influenza disease mechanisms and provide biomarkers and potential treatment options for avian influenza that may re-emerge in the future," said Inge.
In March 2013, China first reported the discovery of the H7N9 avian influenza virus, which can be transmitted from humans to humans, causing severe pneumonia and life-threatening. Since March 2013, more than 200 cases of bird flu have been reported in various parts of China.
Since the research team of Li Lanjuan was involved in the H7N9 avian influenza research in 2013, a series of studies have been carried out. It is found that the live poultry market is the main source of human infection with H7N9. It is found that the H7N9 avian influenza virus-borne gene mutation site has been revealed for the first time. The clinical regularity, the patient's case characteristics, and the successful development of the H7N9 avian influenza virus vaccine strain, developed a rapid diagnostic kit.
In addition, clinically, the research team found for the first time that artificial liver support therapy can effectively eliminate and inhibit cytokine storms and reduce mortality.
“Discovering risks, identifying viruses, elucidating mechanisms, blocking transmission, and finding effective treatments, a series of studies is the key to controlling diseases.†Academician Li Lanjuan said that the research team will continue to pay close attention to the variation and flow of H7N9 avian influenza virus. Further research is conducted on mechanisms, treatment of severe cases, and clinical trials of vaccines.
Source: Chinese Journal of Science
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