(Original title: How is the "Sunflower Collection" of biosimilar drugs made?"
[China Pharmaceutical Network Technology News] Biosimilar drugs are accelerating globally, and the main market share is still controlled by multinational generic companies. How can biosimilars be refined? How can biologics “real biography†be learned?
The first step is to do the foreplay - cell line construction
If you want to learn the "true biography" of biological preparations, you must of course understand the "bottom fineness" of the master - bio-original medicine, and thoroughly analyze the details of the original biological protein structure through reverse bio-engineering technology.
After the master's "bottom" is touched, the DNA fragment can be inserted into a specific cell type, thereby achieving a zero-distance experience and a "living environment" that is almost the same as that of the master.
Then, the generous gene "big" will treat the "new" DNA fragment as equal to other DNA, and the gene will guide the cell to regenerate the desired protein to construct a cell line.
The second step is to focus on cultivating - growth doubling
Just like in a martial arts movie, when a master teaches a proud disciple, he always needs a special “place of practiceâ€, and the same is true for biosimilar drugs.
Now that the cell line has been built, it is necessary to suspend the cultured bioreactor in a nutrient-rich liquid environment where cells will grow.
In such a unique environment, the “cultivation path†of biosimilar drugs naturally goes smoothly. In this process, cells produce targeted biomolecules that are often released into the environment. At this stage, biosimilar drugs have basically been learned as "sacred power."
The third step is to learn the magic, "out of the mountain" - purification
Although "Shen Gong" has been learned, it is necessary to extract the essence of "Shen Gong" before going out of the mountain. After all, only high-quality "Shen Gong" has better and more powerful use value. This is the final step in making biosimilars: purification. Purification requires the use of techniques (eg, chromatography and filtration techniques) to separate biological products from the liquid environment and ultimately extract high purity biological products. At this point, biosimilar drugs are actually made.
[China Pharmaceutical Network Technology News] Biosimilar drugs are accelerating globally, and the main market share is still controlled by multinational generic companies. How can biosimilars be refined? How can biologics “real biography†be learned?
The first step is to do the foreplay - cell line construction
If you want to learn the "true biography" of biological preparations, you must of course understand the "bottom fineness" of the master - bio-original medicine, and thoroughly analyze the details of the original biological protein structure through reverse bio-engineering technology.
After the master's "bottom" is touched, the DNA fragment can be inserted into a specific cell type, thereby achieving a zero-distance experience and a "living environment" that is almost the same as that of the master.
Then, the generous gene "big" will treat the "new" DNA fragment as equal to other DNA, and the gene will guide the cell to regenerate the desired protein to construct a cell line.
The second step is to focus on cultivating - growth doubling
Just like in a martial arts movie, when a master teaches a proud disciple, he always needs a special “place of practiceâ€, and the same is true for biosimilar drugs.
Now that the cell line has been built, it is necessary to suspend the cultured bioreactor in a nutrient-rich liquid environment where cells will grow.
In such a unique environment, the “cultivation path†of biosimilar drugs naturally goes smoothly. In this process, cells produce targeted biomolecules that are often released into the environment. At this stage, biosimilar drugs have basically been learned as "sacred power."
The third step is to learn the magic, "out of the mountain" - purification
Although "Shen Gong" has been learned, it is necessary to extract the essence of "Shen Gong" before going out of the mountain. After all, only high-quality "Shen Gong" has better and more powerful use value. This is the final step in making biosimilars: purification. Purification requires the use of techniques (eg, chromatography and filtration techniques) to separate biological products from the liquid environment and ultimately extract high purity biological products. At this point, biosimilar drugs are actually made.
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