Among the various diseases that cause human death, cardiovascular disease is ranked first. According to data released by the World Health Organization in 2017, about 17.7 million people worldwide die from cardiovascular disease each year, accounting for 31% of all causes of death, and the prevalence and mortality of cardiovascular diseases are increasing year by year. Affect human health.
Polypeptides are effective drugs for the treatment of cardiovascular diseases, but it is currently not possible to use peptides in a non-invasive manner to treat heart diseases such as heart failure. Recent studies by Italian scientists have found that peptide-loaded nanoparticles (calcium phosphate) can be quickly delivered to cardiomyocytes by inhalation, and the polypeptide released by the inhaled particles can be absorbed by cardiomyocytes more quickly than injection. This study has been confirmed in mouse trials and the efficacy of this therapy has also been found in trials in large animals such as pigs. This suggests that inhalation of biocompatible, degradable, polypeptide-loaded nanoparticles would be a viable method for treating heart failure in humans. The research results were published in the latest issue of the international authoritative journal Science Translational Medicine and featured in the cover story.
The application of nanotechnology in the field of health care represents a new development direction of modern medicine. Since the 1990s, the US Food and Drug Administration has approved a variety of nano-drugs that have shown significant advantages in cancer treatment, but few have attempted to apply nanomedicine to cardiovascular disease. According to experts in the study, they conducted this research from the inception of tiny air pollutant particles that can reach human heart and lung cells and endanger human health. (Technology Department)
Active Pharmaceutical Ingredients
Refers to the raw materials used in the production of various preparations, and is the active ingredient in the preparations
Various substances prepared by chemical synthesis, plant extraction or biotechnology are used as medicinal powders, crystals, extracts, etc., but cannot be directly taken by patients.
And the drug in powder, crystal, and extract state is processed into administration forms (such as tablets, capsules, injections, pills, ointments, etc.) that are convenient for patients to take, and these administration forms are called drug dosage forms .
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