[Science] Biomedical 3D printing materials inventory!

In recent years, 3D printing technology is not limited to the development of aerospace, automotive and other manufacturing industries. It is closely integrated with bionic technology, tissue engineering and life sciences, and shines in the medical industry !

Hudi Lipson, a professor of mechanical engineering and computer science at Cornell University, put forward the concept of “3D printing life ladder”, vividly showing the blueprint for the development of 3D printing technology in the medical field.

The bottom layer of the "3D Print Life Stairs" is medical devices that do not need to remain in the body, including medical models, medical instruments, rehabilitation aids, prostheses, etc.; the middle layer is "simple active tissues such as bones and cartilage", that is, personalized permanent implants. Materials, using titanium alloys, bioceramics and high molecular polymers through 3D printing of bones, cartilage, joints, teeth and Other Products, surgically implanted into the human body; further up the veins and skin; close to the top of the ladder is complex and critical Organs such as the heart, liver and brain. Finally, the top level of the life ladder will be the complete unit of life - perhaps one day will be a fully functional artificial life form.

In June 2010, the machine developed by Organovo of the United States to "print on demand" the human living organs required by patients was called a 3D bio-printer (3D biology printer). The technology was named one of the 50 best inventions of 2010 by Time magazine.

3D bio print mode

According to the principle of “layered manufacturing, layer-by-layer stacking”, bio-based 3D printers use biomedical polymer materials, inorganic materials, hydrogel materials and living cells (and related cytokines) according to the three-dimensional simulation “blueprint” of computational aid design. As a "bio-ink", the printed material is added layer by layer on the biocompatible scaffold material until printing is complete.

Subsequently, the naturally occurring cells begin to reorganize and fuse to form a functionally coordinated organic whole. According to the latest research report, Organovo uses bio 3D printing technology to successfully print human liver and survive for 40 days in vitro culture conditions!

Cell 3D printing process

To a certain extent, it can be said that the real charm of bio-3D printing technology is not the technology itself, but the bio-printing materials involved in all aspects of technology. 3D printing technology uses different "ink" materials to produce a variety of artificial organs and tissues that meet the individual requirements of clinical patients. Metals, resins, gypsums, ceramics, polymers, biomacromolecules, etc. are all creatively used in 3D printing to produce biological products.

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