Release date: 2015-11-26
Recently, Canadian scientists announced that they have used the magnetic resonance-guided focused ultrasound device (ExAblate MRgFUS) developed by InSightec of Israel to break through the blood-brain barrier of the brain, thereby improving the treatment level of various brain diseases without surgery. For example, brain tumors, Parkinson's disease, and Alzheimer's disease. This move is of great significance in the field of neuroscience.
The blood-brain barrier is a difficult problem that neuroscience needs to overcome. Finding an effective, especially safe and reversible way to open the blood-brain barrier is one of the main goals of neurological therapy for many years. The blood-brain barrier is the endothelial cells of the brain. The multi-layered membrane formed by these cells tightly wraps all the blood vessels in the brain and blocks bacteria, viruses and other harmful substances from entering the brain. However, the blood-brain barrier has a shielding effect on most drugs. When doctors treat brain tumors or neurological diseases, only about 25% of the drugs can enter the brain, making treatment extremely difficult. The Sennibrook Health Center uses magnetic resonance guided focused ultrasound technology to break through the blood-brain barrier of the human body without craniotomy, so that effective drugs can smoothly enter the brain and achieve therapeutic effects. Even more encouraging is that this technology does not destroy the blood-brain barrier of the human body for a long time. After about 12 hours, the blood-brain barrier recovered and returned to the brain to block harmful substances.
The patient who underwent the medical trial was a 56-year-old female patient with brain cancer. The researchers first injected a microbubble of a chemotherapeutic drug, which then spread to the blood vessels in the brain. Next, the patient wore an ultrasound transmitter with a stereotactic nervous system. The researchers used a magnetic resonance guided focused ultrasound device (ExAblate MRgFUS) to accurately emit a high-intensity focused ultrasound beam, causing microbubble vibrations, forcing endothelial cells that make up the blood-brain barrier. separate. Chemotherapy drugs in the blood can pass through the gap and reach the vicinity of the tumor cells.
The project will test nine other patients with brain tumors and publish the results one year later. Professor Dr. Kullervo Hynynen, who participated in the project, said, “In previous animal experiments, the use of magnetic resonance guided ultrasound equipment (ExAblate MRgFUS) to temporarily open the blood-brain barrier was very effective. If the study shows it Can produce the same effect on the human body, this epoch-making breakthrough will bring new hope to desperate patients."
Developed by Israeli company InSightec, the magnetic resonance guided focused ultrasound device (ExAblate MRgFUS), which played an important role in this breakthrough, is the world's first system to combine two well-recognized medical technologies, magnetic resonance imaging and focused ultrasound. . It was named one of the top 50 inventions in the world in 2011 by American Time Magazine. At present, more than 20 countries, more than 130 hospitals and tens of thousands of patients worldwide have received magnetic resonance guided ultrasound system for uterine fibroids, bone metastases, prostate tumors, and body organs. Device, treatment of brain function, etc.
In China, the instrument has been recognized by domestic experts and has been stationed in six tertiary hospitals, including Peking Union Medical College Hospital, Huashan Hospital, Shanghai First People's Hospital, Fudan Cancer Hospital, Harbin First Hospital, and Jilin University Second. Hospitals, etc., mainly used for non-invasive treatment of uterine fibroids, adenomyosis, and bone metastases.
Source: Phoenix Health
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