Detection of intestinal flora or diagnosis of early liver cancer
August 27, 2018 Source: Health News Network Author: Hou Liang
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, the research team of the First Affiliated Hospital of Zhengzhou University, Zhejiang University, and the First Affiliated Hospital of Xinjiang Medical University has been collaboratively innovating for five years, integrating gene sequencing and big data analysis technology, and successfully constructed a diagnosis model of intestinal flora in early liver cancer. The cross-regional independent verification is realized, which shows the universality of the diagnostic model in the multi-regional population in China. The research paper was published online in the journal "Intestinal" recently.
Due to the lack of specific symptoms and early diagnostic markers in early liver cancer, most patients with liver cancer are diagnosed at an advanced stage with a poor prognosis. The study collected 486 human feces samples from East China, Central China, and Northwest China, and sequenced the gut microbiomes for 419 samples that met the inclusion criteria. The researchers explored the intestinal microecological characteristics of 75 healthy people, 40 compensated cirrhosis patients, and 75 patients with early liver cancer. It was found that the incidence of actinomycetes in early liver cancer patients was increased compared with patients with liver cirrhosis. And 13 species of genus Bacteroides are enriched; compared with healthy individuals, the bacterial genus of butyric acid produced in early liver cancer patients is reduced, and the genus producing lipopolysaccharide is increased.
The researchers further identified microbial markers of early liver cancer and established a diagnostic model with 30 colony markers with high diagnostic accuracy. This diagnostic model achieves a powerful diagnostic capability in early liver cancer and advanced liver cancer in the validation set. More importantly, the diagnostic model showed a strong diagnostic ability for independent samples from 80 liver cancer patients in Zhengzhou and 18 liver cancer patients in Xinjiang, and successfully achieved cross-regional verification of liver cancer diagnostic markers. Therefore, targeting intestinal microecological markers represents a potential non-invasive tool for early diagnosis of liver cancer.
The research paper is the first clinical large sample in the world to describe the intestinal microbial characteristics of liver cancer patients. The successful establishment and cross-regional verification of the intestinal microbial marker diagnostic model for early liver cancer was first reported. Academician Zheng Shusen, Academician Li Lanjuan of Zhejiang University and Professor of the First Affiliated Hospital of Zhengzhou University were the authors of the paper. (Special correspondent Zhou Houliang)
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