According to the Science and Technology Daily, recently, the Department of Cancer Stem Cell Biology of the Kunming Institute of Zoology, Chinese Academy of Sciences has successfully revealed the mechanism by which oncogenes maintain lung cancer.
Lung cancer is one of the most malignant tumors with the fastest growth in morbidity and mortality and the greatest threat to population health and life. In the past 50 years, the incidence and mortality of lung cancer have been significantly increased in many countries. The incidence and mortality of lung cancer in males accounted for the first place among all malignant tumors. The incidence rate of females ranked second and the mortality rate ranked second. The cause of lung cancer is still not fully understood.
It is known that the HUWE1 gene is a ubiquitinated ligase that controls a large number of biological processes closely related to tumorigenesis, such as DNA damage repair, cell proliferation, apoptosis, differentiation, by regulating the stability of the substrate. And cell homeostasis and the like.
The research team used gene manipulation technology to knock out the lung adenocarcinoma cell line and found that HUWE1 deletion significantly inhibited tumor cell proliferation, colony formation and tumorigenic ability. The oncogene HUWE1 is a crucial factor in lung cancer.
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