Natural immunity may help fight cancer development
September 21, 2015 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Cancer immunotherapy, as a cutting-edge therapy in the field of cancer treatment, often protects against cancer cells by enhancing the patient's own immune system function. As of today, scientists in this field focus on developing new cancer vaccines and Engineered to transform lymphocytes to bind to specific proteins produced by cancer cells.
Recently, a research paper published in the international magazine Immunity, scientists from McGill Medical School found that the body's innate immune system can help detect the presence of cancer and limit the development of cancer.
Researcher Professor Saleh said that so far our research has focused on finding specific ways to stimulate adaptive or specific immunity to reject tumors, compared to the patient's body or the specific immunity against cancer. It has been found that innate immunity in the body can help detect the presence of dangerous signals in the body, such as signals generated by the cancer environment, to help us develop immunotherapies that inhibit the development of cancer.
Using mice lacking the innate immune system, the researchers found that the spread of colorectal cancer to the liver is more pronounced in mice with congenital immune system loss than in mice with intact immune systems. Invasive, and this indicates that congenital immunity can effectively control the spread of cancer, and further researchers have identified the sensor Nlrp3 and its effector cytokine IL-18, which can help activate natural killer cells to attack cancer.
In this study, the researchers identified the characteristics of the innate immune system receptors and the mechanisms by which specific factors regulate tumor killing, which may provide new insights into the development of new cancer immunotherapy in the later stages, and also help researchers find more More potential strategies to kill tumor cells.
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