PDX puts medical care into the era of "private customization"

PDX is a "private-customized" individualized tumor animal model

PDX is a sample of a surgical patient and is inoculated into an immunodeficient mouse, which can be further passaged after tumor formation in mice. This model was built to preserve the tissue and genetic characteristics of this tumor patient and maintain the heterogeneity of the tumor. This model has a high correlation with clinical pharmacodynamic results, so they are widely used in drug development.

PDX solves two pain points in preclinical and clinical applications

This model addresses two pain points on the market, one for preclinical applications and one for clinical applications.

In the traditional pre-clinical sense, the screening drugs are all under the skin of the mouse using the ATCC cell line, which we call the Xenograft model. Later, after years of application, we found that this model has less than 5% correlation with clinical. So about 20 years ago, the Germans began to use the tumor samples directly inoculated under the skin of the mice to build the PDX model. After 10-20 years of verification, we found that the correlation between this model and clinical can be as high as 89% to 90%, so the global pharmaceutical companies are now using this model for drug screening.

The second market pain point it solves, there is a lot of randomness and blindness in chemotherapy and targeted drug therapy after surgery. After the first-line drug guide is used, the choice after the second-line drug is very random. In this case, because the PDX model has a high clinical relevance, foreign countries have begun to try to use this model to guide clinical medication through pharmacodynamic results. After years of development, many large foreign hospitals are promoting the clinical application of PDX models in the form of semi-commercial and semi-scientific research.

According to statistics, the five-year survival rate of cancer patients in the world can be as high as 81% in the United States, 65% in Japan and the United Kingdom, but only 25% in China. In fact, domestic treatments and medical devices are not inferior to foreign countries, but why our five-year survival rate is so low. Because many precision medical methods that can be applied to the clinic have not been effectively utilized. Today, I would like to share with you how to use the PDX model to guide precise medications in translational medicine.

Preclinical application of PDX

A large part of PDX in preclinical applications is Mouse Trial, clinical trial on mouse. For example, these patients are patients with pancreatic cancer. PDX, which was built after the tumor sample was cut, was uniformly treated with the preferred drug. In the process of pharmacodynamics, it was found that the pharmacodynamic response of PDX is very close to clinical. It has four different states, including progressive disease, stable disease, partial remission, complete Remmison (complete relief).

Raw materials for animal medicine

Conventional veterinary drug raw materials are: oxytetracycline hydrochloride, doxycycline, chlortetracycline hydrochloride, lincomycin sulfate, gentamycin sulfate, tylosin tartrate, florfenicol, water-soluble amoxicillin, sulfamethoxazole, enno Floxacin lactate, ciprofloxacin hydrochloride, ciprofloxacin hydrochloride, metronidazole, ribavirin, vitamin C, astragalus polysaccharide, penicillin potassium.
The traditional Chinese medicine extracts in veterinary medicines are derived from natural Chinese herbal medicines.
It is purified, concentrated and purified in a different ratio from the original drug. It not only retains the natural state and biological activity of the original drug composition structure, but also retains the harmless and
The beneficial exogenous substance essence realizes the micro-quantification and standardization of Chinese herbal medicine raw materials, and provides a new way for the breeding industry to realize green production. The following herbal extracts for veterinary use: Anti-pathogenic microorganisms Chinese medicine: Anything that can inhibit or kill the reproduction of pathogenic microorganisms and improve the immunity of the body is called anti-pathogenic microorganisms
Chinese herbal medicine. According to the theory of traditional Chinese medicine, it can be divided into heat-clearing medicines, exopathic medicines, diarrhea and water-repelling medicines, damp-damping and diuretic medicines, phlegm-relieving and cough-relieving medicines, qi-regulating and Xiao-shi pharmacological blood medicines, and phlegm-relieving and anti-asthmatic medicines.

Raw materials for animal medicine,Nicarbazin in Feeds,Nosiheptide Veterinary,Nosiheptide Antibacterial,Human Gastric Mucin

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