Pharmacological effects
1. Effect on the immune function of mice: The mice were observed with 50mg/kg or 100mg/kgig aqueous solution to observe various immune function indicators. Results: Spleen and thymus weight increased from 85±12 and 37±6 mg/kg to 140±12 and 53±6 mg/kg; macrophage phagocytosis increased from 53±5% to 78±3%; hemolysin and hemolysis empty The plaque values ​​increased from 147±47 and 0.05±0.1 to 361±62 and 0.18±0.01, respectively; the CAMP content in peritoneal macrophages increased from 100±8.6 pmol/ml to 152±10.9, and the cGMP content was from 62±12 pmol. /ml) decreased to 39±7; increased lymphocyte transformation rate, increased the amount of 3H-TdR incorporation of lymphocytes from 178±19 (cpm) to 589±139; and delayed delayed hypersensitivity from 0.54±0.15 ( Mm) Increase the force 0.82 ± 0.12. It shows that the water-soluble components of the product can enhance the humoral and cellular immunity of mice.
2. Effects on the formation of human lymphocyte E rosette and the activity of acidic a-acetoxynaphtholase esterase (ANAE): The activity of E(Ea) was measured in normal human peripheral blood lymphocytes and drugs after co-incubated at 37°C for 1 hour in vitro. And the total E (Et) flower rate. A rosette was used for ANAE staining. The results showed that when the positive control drugs were porcine thymosin F5 (500ug/ml), levamisole (10ug/ml), and jaundice at low concentration (5mg/ml), Bushen could increase Ea at low concentrations (5mg/ml). Flowering rate, but no effect on the Et flower rate. However, when the concentration is high (50 mg/ml), the Et rose rate can be reduced. In the experiment, porcine thymosin F5 and levamisole did not increase the percentage of ANAE+ lymphocytes. However, when the concentration was high or low, the percentage of ANAE+ lymphocytes decreased. It can be seen that Bushen drugs can promote the formation of Ea rosettes at certain concentrations. The E rosette test is a common method for measuring the number of human T cells, which can reflect the cellular immune function of the body to some extent.
3. The effects of dexamethasone on the delayed footpad reaction in mice: mice ig decoction (60%, 0.5 ml) was administered for 8 consecutive days and challenged with d4ipSRBC. Footpad swelling was measured 24 hours later. The results showed that the relative intensity of the footpad reaction 24 hours after challenge was higher in the Lidang group than in the control group, and that Lidang has the role of promoting cellular immune function in vivo.
4, the role of the digestive system:
4.1. Promote defecation: When each group can significantly reduce the bowel movement time of mice, it has the effect of promoting defecation. At the same time, the morphology of the excreted stool was observed at the same time. For each group, normal or slightly larger fecal pellets were observed. Individual mice (5%) had rare water.
4.2. Effects on mouse small intestine propelling function: Body weight 33±39 female mice. The drug solution and distilled water control solution were mixed with charcoal before use (the amount was 5% of the drug solution). The mice were fasted for 16 hours and then fed 0.6 ml/ig of each test solution, and were sacrificed 20 minutes later. The cesarean section was taken out of the small intestine. From the pylorus to the end of the charcoal movement as the propulsion, the pylorus to the ileocecal valve as the full length, the former in addition to the latter as the degree of advancement. The results showed that each group can significantly increase the degree of small intestine propelling in mice, which proves that the medicine can enhance bowel movement and improve intestinal muscle motor function. 4.3. The antagonistic effect of atropine in inhibiting defecation: weights of 42±39 male mice (8 months) and 46±4 g of female mice (8 months) were randomly divided into 4 groups according to body weight, male and female. After 16 hours of fasting water supply, the water supply group was treated with 0.15 ml/10 g body weight ig test solution. Record the time of ip atropine, the time of ig each test solution and the time of the first red stool in mice, and calculate the laxative time. The results showed that 0.025% atropine significantly inhibited defecation in mice, and that Dangdang was effective against atropine in inhibiting defecation, and there was no significant difference in fighting strength compared with metoclopramide (P>0.47).
4.4. The effect of the column on the water absorption of the large and small intestine of mice: 20 male mice (8mo) weighing 43±3g, 20 female mice (8mo) weighing 43±3g, randomly divided into 4 groups according to body weight, male and female Each half. After 16 hours of fasting and water supply, the control group was treated with 0.15 ml/10 g body weight ig of distilled water, and when the group was ig equal to 50%, it was decoction of the original herbal medicine. Half of the mice were sacrificed 3 hours and 5 hours after dosing. Laparotomy was performed. The ends of the large intestine and small intestine were clamped with hemostatic clips. The large intestine and small intestine were separated and weighed. The hemostatic clips were loosened and immediately placed on the balance. Weighed wet. After drying in an oven at 105°C for 2 hours, the dry weight of the large and small intestine was weighed. The results in Table 4 show that after 5 hours of administration, the water content of the large intestine of the dandang group has a significant difference compared with the control group, indicating that the meat ronge has an inhibitory effect on the water absorption of the large intestine.
5, the pharmacological effects of processed products: Manufactured by different methods of preparation (processing method see the chemical composition of the second), to 0.5g / only dose to mice, a total of 10 days, and Yang Deficiency (hydrocortisone acetate The prepared model) mouse liver spleen DNA synthesis rates were compared. As a result, the DNA synthesis rate in the Yang deficiency group decreased, and the DNA synthesis rate in the treatment group increased. The P values ​​were <0.05 and <0.01, respectively.
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Small packing
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