Sometimes cells "spit it" in order to resist drug treatment, especially cancer cells, which are done when cancer cells are treated with lethal chemotherapy. Researchers from Rockefeller University recently analyzed the atomic-level three-dimensional structure of this "molecular pump" and explored its mechanism of action.
The research was published online in the February 26 issue of Cell. The author of the article was a researcher at Rockefeller University's Jue Chen. Her research group focused on a class of ATP-binding cassette transporters. (ATP-binding cassette, ABC transporters) protein. For the latest study, she said, "This molecular machine can eject many anticancer agents and other drugs, but so far we are not very clear why this type of ejector can recognize and eject multiple substances."
“We found an answer by analyzing how this drug-resistant 'molecular pump' combined with its 'goods' before transshipment,†she added. This new structure will help guide more effective cancer treatments as well as other diseases.
Mysterious multifunction
Multidrug resistanec-associated protein 1 (MRP1) was first identified in drug-resistant lung cancer cells in 1992. Although some proteins have abnormally high abundance of protein expression, it is It is also common in normal cells. MRP1 can be used as a component to protect the brain from the infection barrier. It can also help secrete hormones, deliver immune signaling compounds, and transport other "goods," such as harmful foreign substances. And for modern medicine, MRP1 is not a beneficial factor because it often erroneously transports useful chemicals, including opiates, antidepressants and antibiotics, which are potentially harmful for treatments that require removal of these substances.
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