Researchers at Monash University in Australia have for the first time discovered that immune cells are also present in the eye. This finding is expected to provide new treatments for neovascular retinopathy such as retinopathy of prematurity and diabetic retinopathy.
Researchers at the Department of Diabetes, Monash University's Central Clinical School found that immune cells with regulatory functions, regulatory T cells, are present in the human retina. One of the researchers, Professor Jennifer Wilkinson-Belka, said that the eye has a barrier like the brain, and people used to think that there would be no immune cells in the eye tissue. She believes that this barrier has weaknesses that allow T cells to enter.
Researchers report in the new British journal Nature News that regulatory T cells in the retina can repair damaged retinal blood vessels. In animal experiments, researchers have enhanced the activity of regulatory T cells, significantly reducing the symptoms of retinopathy in prematurity, and they have begun small-scale clinical trials. In addition, animal experiments to verify the effects of regulatory T cells on diabetic retinopathy will also begin.
Neovascular retinopathy refers to the growth of new, abnormal blood vessels on the surface of the retina. As the disease progresses, these new blood vessels leak, rupture and even cause the retina to fall off, causing visual impairment and even blindness.
Among them, retinopathy of prematurity is common in premature infants, which is the main cause of vision loss or even blindness in infants. The disease is currently mainly treated with laser surgery, but the laser can also cause damage to healthy cells while preventing abnormal blood vessel growth, and the condition may continue to deteriorate after treatment. (Xinhua News Agency)
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