Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5

Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5
Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5

AP26113 Basic Info.
CAS:1197958-12-5
Assay:99%
MF:C26H34ClN6O2P
MW529.01
Usage:AP26113 is a kind of effective ALK inhibitors for positive ALK mutations in non-small cell lung cancer.

 

AP26113 is an effective ALK inhibitors, IC50 was 0.62 nM, can overcome due to the effect of Crizotinib resistance of the mediated L1196M mutations. AP26113 highly effective on the sensitive and resistant H3122 cells, reduce the cell growth, inhibition of ALK, phosphate and induction of apoptosis, this effect is dose dependent. Applied to H3122 AP26113 and H3122 CR cells, reduce p - ALK, IC50 were 7.4 and 16.8 nM. AP26113 role in expressing wild-type and mutant EML4 - ALK Ba/F3 cells, reduce the cell number, 24 nM to 10 nM and IC50 respectively.


Wuhan Deme chem Biotechnology Co., Ltd is a new and high-tech enterprise. 
The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .
   

The list of cortical hormone drugs is as follows:
1. We has passed the ISO9001: 2000 (quality management system certification) ISO14001: 2004 (environmental management system certification), OHSMS (occupational health and safety system certification) three system certification, won the "Attaches great importance to contract, keep promise" and won Hubei Province Civilized units and many other honors. 

2.The company's large-scale, solid technical foundation, adequate supply,so that we can meet the different needs of various customers.

3. Professional sales team to meet the various needs of customers, customers timely answers to various questions,achieve good communication,ensure good after-sales service and solve your worries.

4.Improve the logistics system to ensure that customers will konw the movements of goods in the first time after the shipment.

5.To provide third-party product testing reports, integrity management.



Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5
Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5 Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5
Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5

AP26113 Basic Info.
CAS:1197958-12-5
Assay:99%
MF:C26H34ClN6O2P
MW529.01
Usage:AP26113 is a kind of effective ALK inhibitors for positive ALK mutations in non-small cell lung cancer.

 

AP26113 is an effective ALK inhibitors, IC50 was 0.62 nM, can overcome due to the effect of Crizotinib resistance of the mediated L1196M mutations. AP26113 highly effective on the sensitive and resistant H3122 cells, reduce the cell growth, inhibition of ALK, phosphate and induction of apoptosis, this effect is dose dependent. Applied to H3122 AP26113 and H3122 CR cells, reduce p - ALK, IC50 were 7.4 and 16.8 nM. AP26113 role in expressing wild-type and mutant EML4 - ALK Ba/F3 cells, reduce the cell number, 24 nM to 10 nM and IC50 respectively.


Wuhan Deme chem Biotechnology Co., Ltd is a new and high-tech enterprise. 
The main business is research and development, production, sales for Steroid, Active ingredient and Pharmaceutical .
   

The list of cortical hormone drugs is as follows:
1. We has passed the ISO9001: 2000 (quality management system certification) ISO14001: 2004 (environmental management system certification), OHSMS (occupational health and safety system certification) three system certification, won the "Attaches great importance to contract, keep promise" and won Hubei Province Civilized units and many other honors. 

2.The company's large-scale, solid technical foundation, adequate supply,so that we can meet the different needs of various customers.

3. Professional sales team to meet the various needs of customers, customers timely answers to various questions,achieve good communication,ensure good after-sales service and solve your worries.

4.Improve the logistics system to ensure that customers will konw the movements of goods in the first time after the shipment.

5.To provide third-party product testing reports, integrity management.



Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5
Professtional Supply Ap26113 Powder Effective Alk Inhibitors CAS: 1197958-12-5

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