The data shows that a total of 18 people worldwide die every day because they cannot find a suitable organ transplant. But this situation is expected to change, and in the future we may be able to get the right organs through 3D printing.
The author learned that the current Organovo company in the United States has used the 3D printing technology to cultivate human liver tissue, and plans to officially commercialize it at the end of this year. As technology matures, 3D printing will set off an industrial revolution in the medical world.
3D printing in Shanghai medical clinic for nearly 30 years, hundreds of orthopedic patients benefited
A special surgery is underway at the Department of Orthopaedics, the Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine.
This is a patient with a pelvic tumor. After the diagnosis, most of the pelvis is removed and there is a risk of disability. Prof. Dai Kejun, academician of the Chinese Academy of Engineering and director of the orthopaedic department of the hospital, said that according to the previous method, the commonly used "universal" metal products or treated allogeneic bones were used to repair huge bone defects, but the matching was poor and the effect was not good.
Before surgery, they used CT scans and magnetic resonance techniques to collect complete pelvic and tumor data, and through a 3D printing device, printed a complete pelvic model identical to the patient. The doctor performed the simulated resection on the model first, and designed and manufactured the artificial semi-pelvic prosthesis according to the defect of the model, and simulated installation and correction on the model, and then printed the real pelvic prosthesis with titanium alloy. After surgical removal of the tumor, the prosthesis is implanted and precisely attached to the residual pelvis. The final operation was successful and the patient was able to walk.
It is reported that from the late 1980s, Dyke's medical team began to apply 3D printing technology in rapid orthopedics, namely rapid prototyping technology. It has used 3D printing technology to produce hundreds of patients with severe limb and pelvic lesions in the nine hospitals and other hospitals. Individualized bone joints of different parts and shapes repair the prosthesis and succeed.
10 years later, the application market or the ultra-billion "3D printing life ladder" surfaced
Dai Kezhen said that 3D printing technology has a huge space for development in the medical field. That is to say, due to human conditions, local production, unlimited quantity, and cost savings, it can meet the needs of individualized and precise medical treatment.
The pioneer in the current 3D bioprinting field is the US company Organovo. Mike Renard, executive vice president of business operations at the company, said that human liver tissue cultured using 3D printing technology has been used for toxicology prediction and disease modeling, and the first official commercial release is planned for the end of this year.
Hudi Lipson, a professor of mechanical engineering and computer science at Cornell University, proposed a concept of "3D printing life ladder" that aligns parts of the body into a ladder.
The bottom layer of the ladder is an inanimate prosthesis; the middle layer is simple active tissue such as bones and cartilage; the upper part is the vein and the skin; the closest to the top of the ladder is the complex and critical organs such as the heart, liver and brain; the top of the life ladder It will be a complete unit of life - perhaps one day it will be a fully functional artificial life form.
A report released last week by top consulting firm Wohlers predicted that the 3D printing market will reach $6 billion in 2019. In the medical application market share accounted for 15.1%, ranking third. In 2025, the medical market reached 1.9 billion US dollars, equivalent to more than 10 billion yuan.
Macrolide antibiotics
It is a kind of weakly basic antibiotics produced or semi synthesized by Streptomyces. It has 14-16 membered cyclolactone structure.
Shared by human and animal: erythromycin, kitasamycin and Spiramycin
Special for animals: tylosin, tevancomycin, tilmicosin, tylosin, gemicin and tilmicosin
Physical and chemical properties
Weakly alkaline, slightly soluble in water. It is easy to decompose in aqueous solution, especially in acidic condition.
All preparations are salted with inorganic acids, such as phosphoric acid (tylosin, tilmicosin), tartaric acid (tylosin, kitasamycin), thiocyanic acid (erythromycin, erythromycin for animals), lactose acid (erythromycin), and hydrochloric acid (spiramycin).
Antibacterial action
The antibacterial spectrum is narrow: it has antibacterial effect on G + bacteria and some G - bacteria; It has good effect on some spirochetes, chlamydia, mycoplasma and Rickettsia; To produce β- Staphylococcus aureus and Staphylococcus aureus have certain antibacterial activity.
It is usually an antibacterial drug, which can kill bacteria at high concentration.
Tylosin
Special for animals, tartrate (oral), phosphate (premix)
Pharmacology: it has strong effect on G + bacteria and mycoplasma, but weak effect on G - bacteria; It can promote the growth of cattle, pigs and chickens.
Application: it is effective to prevent and cure mycoplasma infection of swine and poultry. The premix can promote the growth.
Preparation: tylosin tartrate soluble powder
Tylosin for injection and Tylosin Injection
Tylosin phosphate premix
Tylosin phosphate + sulfamethazine premix
2. Clinical application
In the pig industry, tylosin is the first choice for the prevention and treatment of swine asthma caused by mycoplasma infection. It can also treat swine dysentery, atrophic rhinitis, arthritis, leptospirosis and so on.
Our business covers Africa, the Middle East, Central Asia and Southeast Asia.
North Africa Egypt, Libya, Tunisia, Morocco, Algeria.
East Africa is Ethiopia, Somalia, Kenya, Tanzania, Uganda, Burundi, Rwanda and Seychelles.
West Africa usually includes Mauritania, Senegal, Gambia, Mali, Burkina Faso, Guinea, Guinea Bissau, Cape Verde, Sierra Leone, Liberia, C ô te d'Ivoire, Ghana, Togo, Benin, Niger, Nigeria, etc.
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Central Asia refers to the inland region of Central Asia: Kazakhstan, Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Afghanistan.
Southeast Asia: Myanmar, Thailand, Cambodia, Laos, Vietnam, Philippines, Malaysia, Singapore, Brunei, Indonesia and Timor Leste.
Countries and regions in West Asia include Saudi Arabia, Iran, Iraq, Kuwait, UAE, Oman, Qatar, Bahrain, Turkey, Israel, Palestine, Syria, Lebanon, Jordan, Yemen, Cyprus, Georgia, Armenia and Azerbaijan.
North African countries and regions include Egypt, Libya, Tunisia, Algeria, Morocco, Madeira Islands, Azores Islands and Western Sahara.
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