With the rabies vaccine production record fraud, "whitening" vaccine test non-compliance and other two Changchun longevity vaccine incident exposure and continued fermentation, the public's attention to vaccine safety is increasing. Where did the problem vaccine flow? These provinces responded one by one.
Changchun longevity problem vaccine incident exposure
On July 15, the State Drug Administration issued a notice on the official website saying that according to the clue, the State Drug Administration organized a flight inspection of Changchun Changsheng Biotechnology Co., Ltd. and found that the company had a record of rabies vaccine production. Falsification and other serious violations of the "Good Manufacturing Practices".
The State Drug Administration requested the Jilin Provincial Food and Drug Administration to take back the “GMP GMP Certificate†(Certificate No.: JL20180024) of the enterprise, ordering to stop the production of rabies vaccine, instructing the enterprise to strictly implement the main responsibility, comprehensively investigate the potential risks, and take the initiative to take control. Measures to ensure the safety of public medication. The investigation team of Jilin Food and Drug Administration stationed in the enterprise and filed a case investigation on relevant violations. The State Drug Administration dispatched a special inspection team to go to Jilin to supervise the investigation and disposal work. All the involved batch products have not been shipped and listed for sale, and all products have been effectively controlled.
In addition, due to the violation of the “prohibition of production and sale of inferior drugs†due to the adsorption of cell-free white-breaking combination vaccine, Changsheng Biotechnology announced on the evening of July 19 that the Changchun Biotechnology Co., Ltd., a wholly-owned subsidiary of Changsheng Biotechnology Co., Ltd. The limited liability company has received the "Administrative Punishment Decision of Jilin Food and Drug Administration" and has been fined 3.44 million yuan.
On the evening of the 22nd, Premier Li Keqiang gave instructions on the vaccine incident: the vaccine incident broke through the moral bottom line of the people and must be clearly explained to the people of the country.
Li Keqiang asked in the instructions that the State Council should immediately send an investigation team to conduct a thorough investigation of the entire process chain of all vaccine production and sales, and ascertain the truth as soon as possible, regardless of which enterprises involved and who are resolutely severely punished and not Palliative. We will resolutely crack down on all illegal and criminal acts that endanger the safety of people's lives, and resolutely punish those who violate the law according to law, and resolutely and severely criticize the behavior of dereliction of duty and dereliction of duty. As soon as possible, the people will have a safe, secure and trustworthy living environment.
Earlier on the same day, the person in charge of the State Food and Drug Administration also reported on the matter, saying that the Jilin Provincial Bureau had already filed an investigation into the enterprise, and the suspected criminal transfer to the public security organs was investigated for criminal responsibility.
Hebei: Unqualified DTP vaccine flows to Shijiazhuang, Langfang and Dingzhou
On July 23, Hebei CDC released a message on the official website that the situation of unqualified adsorption of cell-free white broken combination vaccine produced by Wuhan Biological Products Research Institute Co., Ltd. was sold to Hebei Province. A total of 143,941 people used unqualified vaccines in Shijiazhuang, Langfang and Dingzhou. The unsatisfactory titer of the DTP vaccine may affect the immune protection effect, but has no effect on human safety. After monitoring by the vaccination abnormal reaction monitoring system, no abnormal fluctuations in the suspected vaccination abnormal reaction were found.
In order to ensure the health of children who have passed the unqualified DTP vaccine, Hebei Province uses the qualified DTP vaccine to carry out routine vaccination of the follow-up dose of DTP vaccine according to the immunization procedures prescribed by the state. At the same time, according to the national and provincial Health and Family Planning Commission and the Food and Drug Administration, the provincial CDC and the vaccine enterprises have repeatedly communicated and coordinated, and formed a replanting implementation plan. The company will provide Hebei Province with a variety of replanting. After the white vaccine and the syringe for inoculation, the vaccine and the syringe are in place, the replanting work is carried out quickly.
In addition, on July 21, according to Hebei Radio and Television official WeChat @Hebei Comprehensive Broadcasting, Zhang Zhenguo, director of the Hebei Provincial Center for Disease Control and Prevention, said that the rabies vaccine produced by Changchun Changsheng is in the procurement catalogue of Hebei Province. The disease control agencies throughout the province have completely stopped and sealed the rabies vaccine produced by the company.
Shandong: Unqualified DTP vaccine flows to 8 cities and has inoculated 247,359
According to the Daily News of the People's Republic of China, the Changchun Changsheng Company sold a total of 252,600 unqualified DTP vaccines in Shandong Province, accounting for 3.96% of the province's annual usage, flowing to Jinan, Zibo, Yantai, Jining and Tai'an. 8 cities including Weihai, Rizhao and Laiwu. The batch of vaccines has been inoculated with 247,359, loss and storage of 5,241, involving 215,184 children, and child vaccination information has been registered in the vaccination unit. Involved in children, no abnormal reaction was found to be suspected of vaccination.
On July 18, Shandong Provincial Center for Disease Control and Prevention officially posted on WeChat @山东病控, Shandong Province has completely suspended the human rabies vaccine produced by Changchun Changsheng Biotechnology Co., Ltd., further news, waiting for the State Drug Administration Follow-up notices from departments and vaccine manufacturers.
Guangdong: did not purchase the batch vaccine
Experts from the Guangdong Provincial Center for Disease Control and Prevention responded on the 22nd that the province has not procured the FDA's earlier notification of the vaccination batch of Changchun Changsheng Company's involved batches; the rabies vaccine notified earlier did not go out of the factory, so Guangdong Province There is also no rabies vaccine for the company involved in the batch.
Beijing: did not purchase Changchun Changsheng two problem vaccine
The Beijing Municipal Center for Disease Control and Prevention stated that the two problem vaccines were not purchased in Beijing.
Zhejiang: no problem vaccine inflow
Zhejiang Food and Drug Administration said on the evening of July 22 that after investigation of the vaccine storage and distribution enterprises in Zhejiang Province, the problem of rabies vaccine produced by Changchun Changsheng, which was notified by the State Food and Drug Administration, and the batch number was 201605014-01 "The vaccine has flowed in.
Shanghai: Changchun Changsheng rabies vaccine has been completely discontinued
On July 16, the official website of the Shanghai Municipal Center for Disease Control and Prevention, "WeChat Control" released a message that Shanghai has completely stopped the Changchun Changsheng rabies vaccine. Further information is waiting for the follow-up of the national drug regulatory authorities and vaccine manufacturers. Notice.
According to the Shanghai CDC, if you have been vaccinated with a part of the Changchun Longevity Rabies Vaccine, you can choose another brand of rabies vaccine that also uses the “five-needle methodâ€.
Henan: Suspension of use, local storage of all Changchun Changsheng rabies vaccine
On July 17, according to Dahe.com, Henan Darun Biopharmaceutical Co., Ltd., which is responsible for the promotion, storage and transportation of Changchun Changsheng Vaccine in Henan, informed that the company had notified Henan at 5 pm on July 15. All the county-level CDCs that use Changchun's long-lived rabies vaccine are required to suspend their use and store all rabies vaccines for Changchun's longevity.
According to the above report, as of 12 noon on July 17, the number of Changchun longevity rabies vaccines reported in Henan province was 141380.8 (5 per person), which is estimated to account for the Changchun Changsheng rabies vaccine in Henan market. More than 90% of the amount.
On July 18, Henan Provincial Center for Disease Control and Prevention officially posted on WeChat @æ²³å—病控, saying that there was no vaccine in Henan. In the Q&A article issued by @æ²³å—病控, Henan CDC said that the State Food and Drug Administration announced that all the batch products involved in this flight inspection have not been shipped and listed for sale, and all products have been effectively controlled.
Hainan: Changchun Changsheng rabies vaccine has been completely discontinued
On July 23, Hainan CDC said that Hainan has completely banned the freeze-dried human rabies vaccine produced by Changchun Changsheng Biotechnology Co., Ltd., and the freeze-dried human rabies vaccine from other manufacturers is sufficient to guarantee Hainan rabies exposure. The normal operation of prevention and disposal work.
The Hainan Provincial Center for Disease Control and Prevention reminded that if the company has been vaccinated with the rabies vaccine for freeze-dried humans and has not completed the whole process of vaccination, another brand of freeze-dried human rabies vaccine can be used to continue the vaccination according to the original procedure; Inoculated, waiting for further notification from the State Drug Administration, it is not recommended to revaccinate.
Chongqing: Suspension of use and local storage of Changchun longevity rabies vaccine
On July 18, Chongqing Municipal Center for Disease Control and Prevention, WeChat public number @Chongqing Disease Control announced that since July 15, Chongqing City has suspended the use of quarantine vaccine for lyophilization in Changchun Changsheng Biotechnology Co., Ltd..
Shanxi: Stop using Changchun Longevity Rabies Vaccine
On July 19, the official website of the Shanxi Provincial Center for Disease Control and Prevention released a message saying that according to the notice of the State Drug Administration and the emergency notice of Changchun Changsheng Biotechnology Co., Ltd., the Changchun Changsheng rabies vaccine was stopped at all inoculation points in the province.
All the inoculation points in the province are in accordance with the opinions of the National Health and Health Commission's CDC, and the vaccinators who have been vaccinated with Changchun Changsheng rabies vaccine are selected from other manufacturers' rabies vaccines, and continue to be vaccinated according to the original vaccination program.
Guangxi: 93,384 counties have been recalled in 58 counties (cities, districts)
On July 19th, Guangxi Disease Control and Prevention Center WeChat public number @Guangxi disease control announced that there was no vaccine in Guangxi.
Guangxi CDC mentioned that there are 11 rabies vaccine manufacturers entering the second category of vaccine procurement system of Guangxi Public Resource Trading Center. By July 18, 2018, the distribution of rabies vaccine in the procurement system was 1.5 million. (referring to Changchun Changsheng) the distribution volume is 480,000, accounting for about 32%.
Guangxi CDC said that Changchun Changsheng Company took the initiative to recall itself, which is a company behavior. By July 18, 2018, there were 59,384 recalls in 58 counties (cities, districts) in Guangxi.
According to local media reports on July 20, Guangxi has completely banned the freeze-dried human rabies vaccine produced by Changchun Changsheng Biotechnology Co., Ltd. The autonomous region's disease control department will pay close attention to the progress of this incident and announce relevant treatments in a timely manner. .
Fujian: No batch of rabies vaccines involved in the procurement of unqualified DTP vaccine
On July 23, Fujian CDC WeChat public number @ç¦å»ºCD released a message saying that Fujian Province did not purchase the vaccination index that was previously notified by the State Food and Drug Administration, and failed to pass the vaccine. no effect.
On July 19th, the Fujian Provincial Center for Disease Control and Prevention said that according to the "2018 Fujian Province Second Class Vaccine Purchasing Catalogue", rabies vaccines from 10 manufacturing companies including Changchun Changsheng entered the province's procurement catalogue, and some counties and districts. Purchasing, but since all the batch products of the flight inspection have not been shipped and sold, all products have been effectively controlled.
Qinghai has not responded to whether there is any related problem vaccine inflow
On July 19, Qinghai Provincial Center for Disease Control and Prevention, WeChat public number @é’海病控, it is understood that the State Drug Administration is organizing investigations of enterprises. According to the "Code for the Prevention and Treatment of Rabies Exposure", if the whole process of vaccination is not completed, the rabies vaccine of other manufacturers may be used to continue the vaccination according to the original vaccination program.
Hunan: There is no vaccine in Hunan
On July 20, Hunan CDC WeChat public number @æ¹–å—病控新闻, according to the announcement of the State Drug Administration and the company involved, this inspection of all the involved batch products has not been shipped and listed for sale, all products have been Effective control. On July 16, the company’s Changchun Changsheng issued an announcement stating that in order to ensure the safety of medication, Changchun Changsheng was fully recalling all batches of freeze-dried human rabies vaccines during the validity period. Hunan CDC said that there is no vaccine in Hunan.
Jiangsu: Vaccines are issued through batch inspection, audit and qualified unified bidding procurement
On July 20, according to the official WeChat @ Jiangsu disease control news of Jiangsu Provincial Center for Disease Control and Prevention, the vaccines in various parts of Jiangsu Province have been approved by the batch inspection and examination, and they have been uniformly tendered and purchased through formal channels before they can be distributed to each vaccination. Point for everyone to inoculate.
Jiangsu Disease Control introduced that since 2006, China has implemented a batch issuance system for all listed vaccines, that is, mandatory inspection and audit for each batch of vaccines when they are listed or imported. Under this system, every enterprise produced A batch of biological products must be sampled, sent for inspection, data review and inspection before they can be listed. If the inspection fails or the inspection does not meet the requirements, it may not be listed or imported.
According to the Yangzhou Evening News reported on July 19th, most of Yangzhou City is using the rabies vaccine of Liaoning Chengda. For the small part of the Changchun Changsheng company vaccine, measures have been taken to deal with it: First, actively cooperate with Changchun Changsheng. The company seals its rabies vaccine, the second is to no longer purchase and use its rabies vaccine, and the third is for those who have been vaccinated with Changchun longevity vaccine and have not completed the whole process, according to the rabies vaccination guidelines and the Jiangsu Provincial Class II vaccine guidance. Manufacturers with the same variety of vaccines, complete immunization.
Tibet: Vaccines that have not been procured and used
On July 22, according to the official WeChat @ Tibet disease control news of the Tibet Center for Disease Control and Prevention, the Tibet Autonomous Region CDC attached great importance to the vaccine incident and arranged for special personnel to conduct a strict investigation on the procurement, supply and inventory of the corresponding vaccine. Once again, the Tibet Autonomous Region has never purchased the “human rabies vaccine†and the “adsorption cell-free white-break vaccine†in Changchun Changsheng, and has no business relationship with the company.
Tibet CDC said that it has not purchased the batch of 201607050-2 cell-free white-break vaccine produced by Wuhan Biotechnology (according to the information released by the State Food and Drug Administration, the two batches of vaccines were sold to Shandong, Chongqing and Hebei, etc. Ground). The majority of Tibetan citizens are assured of vaccination.
Shaanxi: Unqualified batches are not purchased
On July 22, according to the report of the China Business News, it was learned from the Shaanxi Provincial Center for Disease Control that Shaanxi Province did not involve the relevant batch of “Daibai Break†vaccine in the bidding procurement, and the public was assured. In addition, the Changchun Changsheng problem, which was detected by the State Food and Drug Administration, has not yet been vaccinated against rabies, and other batches of rabies vaccine produced by the company have also been recalled.
Tianjin: No purchase of Changchun Longevity Rabies Vaccine
On July 22, according to Jinyun News, the person in charge of the Tianjin Center for Disease Control and Prevention said in an interview that the city did not purchase the rabies vaccine produced by Changchun Changsheng.
Tianjin CDC said that the manufacturers of rabies vaccines in Tianjin are: Jilin Maifeng Bio-Pharmaceutical Co., Ltd., Liaoning Chengda Bio-Tech Co., Ltd., Chengdu Kanghua Biological Products Co., Ltd., Guangzhou Nuocheng Biological Products Co., Ltd. Ningbo Rongan Biological Pharmaceutical Co., Ltd. and GlaxoSmithKline Limited.
Sichuan: The problem freeze-dried human rabies vaccine has been fully recalled, did not enter the society
On July 22, according to Sichuan Online, the problem was that the freeze-dried human rabies vaccine had all been recalled and did not enter the society. The problem was that the “white-break†vaccine did not involve the relevant batch of vaccines in the procurement of vaccines in Sichuan Province. So the public can be assured.
Jiangxi: did not purchase the batch vaccine
On July 22, the Jiangxi CDC released a message through the official WeChat, Jiangxi Province did not purchase the batch of vaccines involved.
Anhui: Changchun Changsheng company rabies vaccine is completely decommissioned, the problem is not broken into the vaccine
On July 23, the Anhui Provincial Health and Family Planning Committee posted the Anhui Provincial Center for Disease Control and Prevention on the recent vaccine-related questions. The article said that the rabies vaccine of Changchun Changsheng Company has been completely banned in Anhui Province, and the Changchun Changsheng rabies vaccine has been vaccinated. Those who have not completed the whole process of vaccination, according to the information released by the State Food and Drug Administration and the National Health and Medical Council's CDC and the National Code of Practice for Prevention and Treatment of Rabies Exposure, may use another brand of rabies vaccine according to the original vaccination program. Complete subsequent vaccination.
In addition, Changchun Changsheng Biotechnology Co., Ltd. produced batch number 201605014-01, Wuhan Bioproducts Research Institute Co., Ltd. produced batch number 201607050-2 Baibai broken vaccine titer index does not meet the standard regulations, Anhui Province did not purchase the above batch The next batch of white vaccination vaccine, the above batch of white vaccination vaccine did not flow into the province.
Ningxia: The vaccine has not flowed in, and has stopped buying and using the company's human rabies vaccine.
According to the survey, since 2017, Ningxia has purchased a total of 26,090 human rabies vaccines from Changchun Changsheng Company. 22,258 people have been used and 2 people have been scrapped. At present, 3,830 people have been recalled. The above vaccine is produced by Changchun Changsheng Co., Ltd., but it is not a vaccine batch involved in the notification, and it is a vaccine that has passed the inspection by the drug regulatory department. Regarding the acellular white-break vaccine for the reduction of the effective price of Changchun, mentioned by the State Drug Administration, the involved batch did not flow into Ningxia.
According to the relevant regulations, the Ningxia Autonomous Region CDC will cooperate with relevant departments to cancel the qualification of human rabies vaccine for Changchun Changsheng Biotechnology Co., Ltd., and the region has completely stopped purchasing the human rabies vaccine produced by the company.
If you have used the Changchun Changsheng human rabies vaccine but have not completed the whole vaccination procedure (five-needle method), you can use other manufacturers' rabies vaccine to continue the vaccination according to the original vaccination program. At present, rabies vaccination in the whole district is normal and orderly.
Liaoning: Two batches of DTP vaccines involved in the case have not been supplied to Liaoning Province
The Liaoning Provincial Center for Disease Control and Prevention pointed out that the batch number of the Baibai Broken Vaccine, which was produced by Changchun Changsheng Biotechnology Co., Ltd., was 201605014-01 and the batch number of 201607050-2 produced by Wuhan Biological Products Research Institute Co., Ltd. did not meet the standard. After verification, the two batches of DTP vaccine were not supplied to Liaoning Province.
On July 15, 2018, the State Drug Administration issued a notice and found that Changchun Changsheng Biotechnology Co., Ltd. freeze-dried human rabies vaccine production has serious violations of the "Good Manufacturing Practices". On July 15, 2018, the Circular of the State Drug Administration on the production of freeze-dried human rabies vaccine by Changchun Changsheng Biotechnology Co., Ltd. clearly stated that all the rabies vaccines involved in the batch were not shipped and sold.
Inner Mongolia: No rabies vaccine and DTP vaccine
On the 23rd, the Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention announced that there is no rabies vaccine and white vaccination in Inner Mongolia.
The news said that the State Drug Administration issued a flight inspection of Changchun Changsheng Biotechnology Co., Ltd. "freeze-dried human rabies vaccine production record fraud" announcement, the sale of frozen rabies vaccine for people in Inner Mongolia, has been The company independently recalled itself.
At the same time, Inner Mongolia has not purchased the batch number 201606014-01 produced by Changchun Changsheng Biotechnology Co., Ltd. and the batch number 201607050-2 produced by Wuhan Biological Products Research Institute Co., Ltd.
Yunnan: No batch of vaccine rabies vaccine is supplied by multiple manufacturers
On July 23, the Yunnan Provincial Center for Disease Control and Prevention issued a report saying: “There are no batch vaccines (including DTP vaccine and rabies vaccine) in Yunnan, and the rabies vaccine in Yunnan Province is supplied by many manufacturers. Will affect the vaccination of the rabies vaccine at the inoculation point."
Changchun longevity problem vaccine incident exposure
On July 15, the State Drug Administration issued a notice on the official website saying that according to the clue, the State Drug Administration organized a flight inspection of Changchun Changsheng Biotechnology Co., Ltd. and found that the company had a record of rabies vaccine production. Falsification and other serious violations of the "Good Manufacturing Practices".
The State Drug Administration requested the Jilin Provincial Food and Drug Administration to take back the “GMP GMP Certificate†(Certificate No.: JL20180024) of the enterprise, ordering to stop the production of rabies vaccine, instructing the enterprise to strictly implement the main responsibility, comprehensively investigate the potential risks, and take the initiative to take control. Measures to ensure the safety of public medication. The investigation team of Jilin Food and Drug Administration stationed in the enterprise and filed a case investigation on relevant violations. The State Drug Administration dispatched a special inspection team to go to Jilin to supervise the investigation and disposal work. All the involved batch products have not been shipped and listed for sale, and all products have been effectively controlled.
In addition, due to the violation of the “prohibition of production and sale of inferior drugs†due to the adsorption of cell-free white-breaking combination vaccine, Changsheng Biotechnology announced on the evening of July 19 that the Changchun Biotechnology Co., Ltd., a wholly-owned subsidiary of Changsheng Biotechnology Co., Ltd. The limited liability company has received the "Administrative Punishment Decision of Jilin Food and Drug Administration" and has been fined 3.44 million yuan.
On the evening of the 22nd, Premier Li Keqiang gave instructions on the vaccine incident: the vaccine incident broke through the moral bottom line of the people and must be clearly explained to the people of the country.
Li Keqiang asked in the instructions that the State Council should immediately send an investigation team to conduct a thorough investigation of the entire process chain of all vaccine production and sales, and ascertain the truth as soon as possible, regardless of which enterprises involved and who are resolutely severely punished and not Palliative. We will resolutely crack down on all illegal and criminal acts that endanger the safety of people's lives, and resolutely punish those who violate the law according to law, and resolutely and severely criticize the behavior of dereliction of duty and dereliction of duty. As soon as possible, the people will have a safe, secure and trustworthy living environment.
Earlier on the same day, the person in charge of the State Food and Drug Administration also reported on the matter, saying that the Jilin Provincial Bureau had already filed an investigation into the enterprise, and the suspected criminal transfer to the public security organs was investigated for criminal responsibility.
Hebei: Unqualified DTP vaccine flows to Shijiazhuang, Langfang and Dingzhou
On July 23, Hebei CDC released a message on the official website that the situation of unqualified adsorption of cell-free white broken combination vaccine produced by Wuhan Biological Products Research Institute Co., Ltd. was sold to Hebei Province. A total of 143,941 people used unqualified vaccines in Shijiazhuang, Langfang and Dingzhou. The unsatisfactory titer of the DTP vaccine may affect the immune protection effect, but has no effect on human safety. After monitoring by the vaccination abnormal reaction monitoring system, no abnormal fluctuations in the suspected vaccination abnormal reaction were found.
In order to ensure the health of children who have passed the unqualified DTP vaccine, Hebei Province uses the qualified DTP vaccine to carry out routine vaccination of the follow-up dose of DTP vaccine according to the immunization procedures prescribed by the state. At the same time, according to the national and provincial Health and Family Planning Commission and the Food and Drug Administration, the provincial CDC and the vaccine enterprises have repeatedly communicated and coordinated, and formed a replanting implementation plan. The company will provide Hebei Province with a variety of replanting. After the white vaccine and the syringe for inoculation, the vaccine and the syringe are in place, the replanting work is carried out quickly.
In addition, on July 21, according to Hebei Radio and Television official WeChat @Hebei Comprehensive Broadcasting, Zhang Zhenguo, director of the Hebei Provincial Center for Disease Control and Prevention, said that the rabies vaccine produced by Changchun Changsheng is in the procurement catalogue of Hebei Province. The disease control agencies throughout the province have completely stopped and sealed the rabies vaccine produced by the company.
Shandong: Unqualified DTP vaccine flows to 8 cities and has inoculated 247,359
According to the Daily News of the People's Republic of China, the Changchun Changsheng Company sold a total of 252,600 unqualified DTP vaccines in Shandong Province, accounting for 3.96% of the province's annual usage, flowing to Jinan, Zibo, Yantai, Jining and Tai'an. 8 cities including Weihai, Rizhao and Laiwu. The batch of vaccines has been inoculated with 247,359, loss and storage of 5,241, involving 215,184 children, and child vaccination information has been registered in the vaccination unit. Involved in children, no abnormal reaction was found to be suspected of vaccination.
On July 18, Shandong Provincial Center for Disease Control and Prevention officially posted on WeChat @山东病控, Shandong Province has completely suspended the human rabies vaccine produced by Changchun Changsheng Biotechnology Co., Ltd., further news, waiting for the State Drug Administration Follow-up notices from departments and vaccine manufacturers.
Guangdong: did not purchase the batch vaccine
Experts from the Guangdong Provincial Center for Disease Control and Prevention responded on the 22nd that the province has not procured the FDA's earlier notification of the vaccination batch of Changchun Changsheng Company's involved batches; the rabies vaccine notified earlier did not go out of the factory, so Guangdong Province There is also no rabies vaccine for the company involved in the batch.
Beijing: did not purchase Changchun Changsheng two problem vaccine
The Beijing Municipal Center for Disease Control and Prevention stated that the two problem vaccines were not purchased in Beijing.
Zhejiang: no problem vaccine inflow
Zhejiang Food and Drug Administration said on the evening of July 22 that after investigation of the vaccine storage and distribution enterprises in Zhejiang Province, the problem of rabies vaccine produced by Changchun Changsheng, which was notified by the State Food and Drug Administration, and the batch number was 201605014-01 "The vaccine has flowed in.
Shanghai: Changchun Changsheng rabies vaccine has been completely discontinued
On July 16, the official website of the Shanghai Municipal Center for Disease Control and Prevention, "WeChat Control" released a message that Shanghai has completely stopped the Changchun Changsheng rabies vaccine. Further information is waiting for the follow-up of the national drug regulatory authorities and vaccine manufacturers. Notice.
According to the Shanghai CDC, if you have been vaccinated with a part of the Changchun Longevity Rabies Vaccine, you can choose another brand of rabies vaccine that also uses the “five-needle methodâ€.
Henan: Suspension of use, local storage of all Changchun Changsheng rabies vaccine
On July 17, according to Dahe.com, Henan Darun Biopharmaceutical Co., Ltd., which is responsible for the promotion, storage and transportation of Changchun Changsheng Vaccine in Henan, informed that the company had notified Henan at 5 pm on July 15. All the county-level CDCs that use Changchun's long-lived rabies vaccine are required to suspend their use and store all rabies vaccines for Changchun's longevity.
According to the above report, as of 12 noon on July 17, the number of Changchun longevity rabies vaccines reported in Henan province was 141380.8 (5 per person), which is estimated to account for the Changchun Changsheng rabies vaccine in Henan market. More than 90% of the amount.
On July 18, Henan Provincial Center for Disease Control and Prevention officially posted on WeChat @æ²³å—病控, saying that there was no vaccine in Henan. In the Q&A article issued by @æ²³å—病控, Henan CDC said that the State Food and Drug Administration announced that all the batch products involved in this flight inspection have not been shipped and listed for sale, and all products have been effectively controlled.
Hainan: Changchun Changsheng rabies vaccine has been completely discontinued
On July 23, Hainan CDC said that Hainan has completely banned the freeze-dried human rabies vaccine produced by Changchun Changsheng Biotechnology Co., Ltd., and the freeze-dried human rabies vaccine from other manufacturers is sufficient to guarantee Hainan rabies exposure. The normal operation of prevention and disposal work.
The Hainan Provincial Center for Disease Control and Prevention reminded that if the company has been vaccinated with the rabies vaccine for freeze-dried humans and has not completed the whole process of vaccination, another brand of freeze-dried human rabies vaccine can be used to continue the vaccination according to the original procedure; Inoculated, waiting for further notification from the State Drug Administration, it is not recommended to revaccinate.
Chongqing: Suspension of use and local storage of Changchun longevity rabies vaccine
On July 18, Chongqing Municipal Center for Disease Control and Prevention, WeChat public number @Chongqing Disease Control announced that since July 15, Chongqing City has suspended the use of quarantine vaccine for lyophilization in Changchun Changsheng Biotechnology Co., Ltd..
Shanxi: Stop using Changchun Longevity Rabies Vaccine
On July 19, the official website of the Shanxi Provincial Center for Disease Control and Prevention released a message saying that according to the notice of the State Drug Administration and the emergency notice of Changchun Changsheng Biotechnology Co., Ltd., the Changchun Changsheng rabies vaccine was stopped at all inoculation points in the province.
All the inoculation points in the province are in accordance with the opinions of the National Health and Health Commission's CDC, and the vaccinators who have been vaccinated with Changchun Changsheng rabies vaccine are selected from other manufacturers' rabies vaccines, and continue to be vaccinated according to the original vaccination program.
Guangxi: 93,384 counties have been recalled in 58 counties (cities, districts)
On July 19th, Guangxi Disease Control and Prevention Center WeChat public number @Guangxi disease control announced that there was no vaccine in Guangxi.
Guangxi CDC mentioned that there are 11 rabies vaccine manufacturers entering the second category of vaccine procurement system of Guangxi Public Resource Trading Center. By July 18, 2018, the distribution of rabies vaccine in the procurement system was 1.5 million. (referring to Changchun Changsheng) the distribution volume is 480,000, accounting for about 32%.
Guangxi CDC said that Changchun Changsheng Company took the initiative to recall itself, which is a company behavior. By July 18, 2018, there were 59,384 recalls in 58 counties (cities, districts) in Guangxi.
According to local media reports on July 20, Guangxi has completely banned the freeze-dried human rabies vaccine produced by Changchun Changsheng Biotechnology Co., Ltd. The autonomous region's disease control department will pay close attention to the progress of this incident and announce relevant treatments in a timely manner. .
Fujian: No batch of rabies vaccines involved in the procurement of unqualified DTP vaccine
On July 23, Fujian CDC WeChat public number @ç¦å»ºCD released a message saying that Fujian Province did not purchase the vaccination index that was previously notified by the State Food and Drug Administration, and failed to pass the vaccine. no effect.
On July 19th, the Fujian Provincial Center for Disease Control and Prevention said that according to the "2018 Fujian Province Second Class Vaccine Purchasing Catalogue", rabies vaccines from 10 manufacturing companies including Changchun Changsheng entered the province's procurement catalogue, and some counties and districts. Purchasing, but since all the batch products of the flight inspection have not been shipped and sold, all products have been effectively controlled.
Qinghai has not responded to whether there is any related problem vaccine inflow
On July 19, Qinghai Provincial Center for Disease Control and Prevention, WeChat public number @é’海病控, it is understood that the State Drug Administration is organizing investigations of enterprises. According to the "Code for the Prevention and Treatment of Rabies Exposure", if the whole process of vaccination is not completed, the rabies vaccine of other manufacturers may be used to continue the vaccination according to the original vaccination program.
Hunan: There is no vaccine in Hunan
On July 20, Hunan CDC WeChat public number @æ¹–å—病控新闻, according to the announcement of the State Drug Administration and the company involved, this inspection of all the involved batch products has not been shipped and listed for sale, all products have been Effective control. On July 16, the company’s Changchun Changsheng issued an announcement stating that in order to ensure the safety of medication, Changchun Changsheng was fully recalling all batches of freeze-dried human rabies vaccines during the validity period. Hunan CDC said that there is no vaccine in Hunan.
Jiangsu: Vaccines are issued through batch inspection, audit and qualified unified bidding procurement
On July 20, according to the official WeChat @ Jiangsu disease control news of Jiangsu Provincial Center for Disease Control and Prevention, the vaccines in various parts of Jiangsu Province have been approved by the batch inspection and examination, and they have been uniformly tendered and purchased through formal channels before they can be distributed to each vaccination. Point for everyone to inoculate.
Jiangsu Disease Control introduced that since 2006, China has implemented a batch issuance system for all listed vaccines, that is, mandatory inspection and audit for each batch of vaccines when they are listed or imported. Under this system, every enterprise produced A batch of biological products must be sampled, sent for inspection, data review and inspection before they can be listed. If the inspection fails or the inspection does not meet the requirements, it may not be listed or imported.
According to the Yangzhou Evening News reported on July 19th, most of Yangzhou City is using the rabies vaccine of Liaoning Chengda. For the small part of the Changchun Changsheng company vaccine, measures have been taken to deal with it: First, actively cooperate with Changchun Changsheng. The company seals its rabies vaccine, the second is to no longer purchase and use its rabies vaccine, and the third is for those who have been vaccinated with Changchun longevity vaccine and have not completed the whole process, according to the rabies vaccination guidelines and the Jiangsu Provincial Class II vaccine guidance. Manufacturers with the same variety of vaccines, complete immunization.
Tibet: Vaccines that have not been procured and used
On July 22, according to the official WeChat @ Tibet disease control news of the Tibet Center for Disease Control and Prevention, the Tibet Autonomous Region CDC attached great importance to the vaccine incident and arranged for special personnel to conduct a strict investigation on the procurement, supply and inventory of the corresponding vaccine. Once again, the Tibet Autonomous Region has never purchased the “human rabies vaccine†and the “adsorption cell-free white-break vaccine†in Changchun Changsheng, and has no business relationship with the company.
Tibet CDC said that it has not purchased the batch of 201607050-2 cell-free white-break vaccine produced by Wuhan Biotechnology (according to the information released by the State Food and Drug Administration, the two batches of vaccines were sold to Shandong, Chongqing and Hebei, etc. Ground). The majority of Tibetan citizens are assured of vaccination.
Shaanxi: Unqualified batches are not purchased
On July 22, according to the report of the China Business News, it was learned from the Shaanxi Provincial Center for Disease Control that Shaanxi Province did not involve the relevant batch of “Daibai Break†vaccine in the bidding procurement, and the public was assured. In addition, the Changchun Changsheng problem, which was detected by the State Food and Drug Administration, has not yet been vaccinated against rabies, and other batches of rabies vaccine produced by the company have also been recalled.
Tianjin: No purchase of Changchun Longevity Rabies Vaccine
On July 22, according to Jinyun News, the person in charge of the Tianjin Center for Disease Control and Prevention said in an interview that the city did not purchase the rabies vaccine produced by Changchun Changsheng.
Tianjin CDC said that the manufacturers of rabies vaccines in Tianjin are: Jilin Maifeng Bio-Pharmaceutical Co., Ltd., Liaoning Chengda Bio-Tech Co., Ltd., Chengdu Kanghua Biological Products Co., Ltd., Guangzhou Nuocheng Biological Products Co., Ltd. Ningbo Rongan Biological Pharmaceutical Co., Ltd. and GlaxoSmithKline Limited.
Sichuan: The problem freeze-dried human rabies vaccine has been fully recalled, did not enter the society
On July 22, according to Sichuan Online, the problem was that the freeze-dried human rabies vaccine had all been recalled and did not enter the society. The problem was that the “white-break†vaccine did not involve the relevant batch of vaccines in the procurement of vaccines in Sichuan Province. So the public can be assured.
Jiangxi: did not purchase the batch vaccine
On July 22, the Jiangxi CDC released a message through the official WeChat, Jiangxi Province did not purchase the batch of vaccines involved.
Anhui: Changchun Changsheng company rabies vaccine is completely decommissioned, the problem is not broken into the vaccine
On July 23, the Anhui Provincial Health and Family Planning Committee posted the Anhui Provincial Center for Disease Control and Prevention on the recent vaccine-related questions. The article said that the rabies vaccine of Changchun Changsheng Company has been completely banned in Anhui Province, and the Changchun Changsheng rabies vaccine has been vaccinated. Those who have not completed the whole process of vaccination, according to the information released by the State Food and Drug Administration and the National Health and Medical Council's CDC and the National Code of Practice for Prevention and Treatment of Rabies Exposure, may use another brand of rabies vaccine according to the original vaccination program. Complete subsequent vaccination.
In addition, Changchun Changsheng Biotechnology Co., Ltd. produced batch number 201605014-01, Wuhan Bioproducts Research Institute Co., Ltd. produced batch number 201607050-2 Baibai broken vaccine titer index does not meet the standard regulations, Anhui Province did not purchase the above batch The next batch of white vaccination vaccine, the above batch of white vaccination vaccine did not flow into the province.
Ningxia: The vaccine has not flowed in, and has stopped buying and using the company's human rabies vaccine.
According to the survey, since 2017, Ningxia has purchased a total of 26,090 human rabies vaccines from Changchun Changsheng Company. 22,258 people have been used and 2 people have been scrapped. At present, 3,830 people have been recalled. The above vaccine is produced by Changchun Changsheng Co., Ltd., but it is not a vaccine batch involved in the notification, and it is a vaccine that has passed the inspection by the drug regulatory department. Regarding the acellular white-break vaccine for the reduction of the effective price of Changchun, mentioned by the State Drug Administration, the involved batch did not flow into Ningxia.
According to the relevant regulations, the Ningxia Autonomous Region CDC will cooperate with relevant departments to cancel the qualification of human rabies vaccine for Changchun Changsheng Biotechnology Co., Ltd., and the region has completely stopped purchasing the human rabies vaccine produced by the company.
If you have used the Changchun Changsheng human rabies vaccine but have not completed the whole vaccination procedure (five-needle method), you can use other manufacturers' rabies vaccine to continue the vaccination according to the original vaccination program. At present, rabies vaccination in the whole district is normal and orderly.
Liaoning: Two batches of DTP vaccines involved in the case have not been supplied to Liaoning Province
The Liaoning Provincial Center for Disease Control and Prevention pointed out that the batch number of the Baibai Broken Vaccine, which was produced by Changchun Changsheng Biotechnology Co., Ltd., was 201605014-01 and the batch number of 201607050-2 produced by Wuhan Biological Products Research Institute Co., Ltd. did not meet the standard. After verification, the two batches of DTP vaccine were not supplied to Liaoning Province.
On July 15, 2018, the State Drug Administration issued a notice and found that Changchun Changsheng Biotechnology Co., Ltd. freeze-dried human rabies vaccine production has serious violations of the "Good Manufacturing Practices". On July 15, 2018, the Circular of the State Drug Administration on the production of freeze-dried human rabies vaccine by Changchun Changsheng Biotechnology Co., Ltd. clearly stated that all the rabies vaccines involved in the batch were not shipped and sold.
Inner Mongolia: No rabies vaccine and DTP vaccine
On the 23rd, the Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention announced that there is no rabies vaccine and white vaccination in Inner Mongolia.
The news said that the State Drug Administration issued a flight inspection of Changchun Changsheng Biotechnology Co., Ltd. "freeze-dried human rabies vaccine production record fraud" announcement, the sale of frozen rabies vaccine for people in Inner Mongolia, has been The company independently recalled itself.
At the same time, Inner Mongolia has not purchased the batch number 201606014-01 produced by Changchun Changsheng Biotechnology Co., Ltd. and the batch number 201607050-2 produced by Wuhan Biological Products Research Institute Co., Ltd.
Yunnan: No batch of vaccine rabies vaccine is supplied by multiple manufacturers
On July 23, the Yunnan Provincial Center for Disease Control and Prevention issued a report saying: “There are no batch vaccines (including DTP vaccine and rabies vaccine) in Yunnan, and the rabies vaccine in Yunnan Province is supplied by many manufacturers. Will affect the vaccination of the rabies vaccine at the inoculation point."
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