Daxie Liangdian Nobel Prize Prize "cell autophagy" status has a new detection technology

The Japanese scientist Otsuka Liangdan won the Nobel Prize in Physiology or Medicine this year for his research on the mechanism of autophagy. Japanese researchers have recently invented a new technology that can easily detect the state of autophagy in cells, which will help to develop new drugs using the mechanism of autophagy.

The mechanism of autophagy refers to the ability of cells to maintain their life by providing nutrients and energy by degrading their own non-essential ingredients in response to transient stress. Autophagy can also degrade potentially toxic proteins to prevent cell damage or prevent apoptosis. The autophagy mechanism is associated with many diseases such as Alzheimer's disease.

According to Japanese media reports, the University of Tokyo professor Mizushima and others published the latest research results on the mechanism of autophagy in the new edition of the American Journal of Molecular Cell. Shuidaosheng worked in the laboratory of the Nobel Prize winner, and was an important assistant and student of the Dalai Lama.

The researchers used gene editing methods to make cells produce fluorescent protein. It was found that as the autophagy progressed, the fluorescence gradually changed from blue to green, yellow and red, so that the state of autophagy could be measured in real time. In animal cell experiments, the researchers tested a variety of drugs, and found that 47 drugs can promote autophagy, and 43 drugs can block autophagy.

The researchers say that drugs that block autophagy can be an effective anticancer agent for cancer types that depend on the pathogenesis of autophagy. In other diseases, drugs that induce autophagy can be used in a targeted manner. In the future, this technology is expected to be applied to drug development related to the mechanism of autophagy.