The first therapeutic AIDS vaccine will be available
February 27, 2017 Source: Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];According to the "New Scientist" magazine website on the 22nd, recently in the United States in Seattle, the retrovirus and opportunistic infection meeting, Spain's IrsiCaixa AIDS Institute Beadris Moss announced a surprising new treatment for AIDS Sexual Vaccine Clinical Trial Results: Virus replication in five HIV (HIV) carriers was not only successfully inhibited, but the time to stop taking antiretroviral drugs (ART) exceeded 4 weeks for the first time, one of which even reached 7 months. Long.
In order to prevent the virus from causing damage to the immune system, HIV-infected people need to take ART every day or even for life. Although taking ART has been shown to be effective in suppressing AIDS episodes, these drugs are expensive, time consuming, and have serious side effects.
Three years ago, Moser led the team to conduct human clinical trials on two HIV vaccines developed at the University of Oxford in the United Kingdom. At that time, 24 newly diagnosed HIV-infected people participated in the trial. They all took ART drugs to test whether the vaccine could be stimulated. A strong immune response.
This time, Moser designed a new test procedure for 15 of them, first giving them a large dose of one of the vaccines; then injecting a three-fold dose of the anticancer drug romidepsin, which has been proven Effectively remove HIV that is lurking in the body; finally, give each person a large dose of another vaccine and stop taking ART.
The results showed that although 10 of them had a rapid rebound in viral content and had to retake ART, the other five people successfully suppressed the virus, and the withdrawal time lasted for 6 weeks, 14 weeks, 19 weeks, 21 weeks. The longest is up to 7 months. Mose said that they occasionally detected HIV in the subject, but the amount did not exceed the limit of the need to restore ART. They will continue to observe the maximum time each subject can persist.
Experts at the meeting said that the test results were exciting. Although the new vaccine did not achieve efficacy in 2/3 carriers, the positive effects of the other five people proved that the first HIV-treated vaccine that stopped taking the drug also prevented the virus from replicating. Or will come out. In a similar trial conducted in a new HIV-infected patient, up to 10% of the patients were able to control the spread of the virus after discontinuation, and the long-term withdrawal time did not exceed 4 weeks.
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