Pharmacology
1. The half-lethal dose of intravenous infusion of mice was 6.10±0.26g/kg, and that of total etcholone was 18.7±2.0mg/kg, equivalent to crude drug 9.35±1.Og/kg. The median lethal dose of rat infusion was 75.1±13.1g/kg, and it was injected intraperitoneally 0.1-1.Og/kg once a day for 3 months. There was no abnormality in body weight, urinary sediment and urinary protein examination. The use of drugs in the feces is relatively dilute, indicating that there is a certain degree of diarrhea. Some pathological schizophrenia patients had mild turbid swelling and no organic lesions were found.
2. The LD50 of iv lobelia decoction mice was 6.10±0.26g (crude drug)/kg. Before the death, there was breathing excitement, arrogance and restlessness, followed by convulsions, and died within 5 minutes. The LD50 of ig of Lobelia chinensis extract was 95.1±13.1g (crude drug)/kg. Daily ip infusions of 0.1, 0.3 and 1.0 g (crude drug)/kg for 3 consecutive minutes, no abnormalities were found in body weight, urinary sediment, and urinary protein examination.
3. Pathological examination showed no significant organic changes except some mild renal edema in rats.
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