Pharmacological applications
1. Anti-tumor effect: A variety of alkaloids in Sophora flavescens root can inhibit the mouse sarcoma S180, sarcoma S37, murine cervical cancer U14, Yoshida sarcoma, and ascites type liver cancer. In addition, Oxymatrine on tumor oxygen cells Has a selective killing effect.
2. Effects on cardiovascular system: Total root alkalinum has antihypertensive effect, and this effect may be related to its role in vasodilation. Shandougen total alkaloids also significantly increased coronary flow in guinea pig hearts. The strength of the effect was not related to the enhancement of myocardial contractility. It was a direct crown expansion effect.
3, the impact on immune function: Shandougen injection of intraperitoneal injection can significantly inhibit the phagocytic function of mouse peritoneal macrophages.
4. Effects on the central nervous system: Shandougen can inhibit the spontaneous activity of mice, antagonize the excitatory action of amphetamine, and strengthen the inhibitory effect of pentobarbital sodium, thiopental sodium, and chloral hydrate on the central nervous system.
5, anti-ulcer effect.
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